ea0014s5.1 | Novel bioactive peptides – lessons from animals | ECE2007
Vaudry Hubert
, Tostivint Hervé
, Lihrmann Isabelle
, Chartrel Nicolas
, Fournier Alain
, Leprince Jérôme
, Tonon Marie-Christine
, Conlon J. Michael
The concentration of many neuropeptides in the brains of ectothermic vertebrates is several orders of magnitude higher than in the brains of mammals. We have taken advantage of this singular situation to isolate from the brain of the European green frog, Rana esculenta, a number of regulatory peptides that are orthologous to mammalian neuroendocrine peptides. These include α-MSH, γ-MSH, two tachykinins, two GnRH variants, CRH, PACAP, NPY, CGRP, CNP, GRP, and O...